[Producer Theron Bamberger] opened the fly leave and looked at the cast of characters. “Twenty-two characters,” he said. “Too many.” And the play was returned forthwith to Mr. Rice. ~ New York Times, Adele Nathan, 2/2/1947
The play would go on to win the Pulitzer Prize and be adapted into a Tony Award winning Opera. The family tragedy at the center branches off into subplots and vignettes for the neighbors and vendors that visit the central brownstone, expanding the cast from 22 to 30.
On a side note, I'm realizing that the slice of life structure, and the brownstone set, had an influence on 2004's Avenue Q.